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ClonePix2

A complete solution for the automated screening and objective selection of high-value clones across diverse cell types.

The ClonePix® 2 Mammalian Colony Picker is a fully automated system for selecting high-value clones used in antibody discovery and cell line development. Screen more clones in less time with monoclonal verification on day zero, then screen and identify for highest producers in weeks, not months.

Hybridomas, CHO cells, stem cells and other cell types are imaged and selected based on user-defined parameters. Plate handling, barcode reading, and picking are fully integrated, and all data, including images, are saved for downstream analysis. The picker increases the probability of finding optimally produced cell lines and significantly reduces time and labor.

 

Redefine clone screening and selection with transformative cell line development workflows

Empower your team with data analysis that automatically generates a map of clones and their secretion levels from a series of images generated in situ. The ClonePix can also be customized to include image-based monoclonality assurance on day zero.* This means your team can screen in one round and then pick for the highest produces in weeks, not months.

Enhanced for Monoclonality Verification*

Offering high-resolution single-cell imaging capability on day 0

The enhanced ClonePix 2 system can automatically screen and pick clones that are both high-producing and monoclonal—all in one system. Screen more clones in less time with monoclonal verification on day zero, then screen and pick the highest producers in less than two weeks.

Key Benefits:

  • Rapid Monoclonal Verification: Achieve image-based clonality verification on day zero, reducing screening rounds from two to one.
  • Advanced Imaging Capabilities: Rapid Z-stack acquisition allows detection of single cells throughout the medium volume, not just a single focal plane.
  • Streamlined Workflow: Simplified process from single-cell identification to productivity screening, enhancing efficiency with the all-in-one system.
  • Higher Throughput: Process up to 12,000 colonies on just 10 plates, significantly increasing laboratory productivity.
  • Cost-Effective Operations: Minimize operational costs through reduced manual labor, decreased media volume requirements, and enhanced processing speed.

Enhanced for stem cell applications*

Identify desirable, clonal stem cell colonies for high-throughput colony screening and picking

High-resolution imaging identifies desirable, clonal stem cell colonies for high-throughput colony screening and picking. Specialized picking pins allow the gentle transfer of adherent, feeder-free cells to high-density plates for clonal expansion and downstream analysis.

  • Colony formation - Individual stem cells plated at a low density in 6-well plates divide and develop into colonies. Plating density is kept low to ensure that colonies are derived from a single parent cell.
  • Clone screening - Clonally-derived stem cell colonies are identified by their desirable morphological characteristics and are picked from the low-density 6-well plates into higher density 96-well plates to carry forward with the screening. The ClonePix® 2 Mammalian Colony Picker can be customized with high-resolution optics and stem cell-specific pins, allowing this established technology to be leveraged in stem cell workflows.
  • Cell growth - Cell growth is determined by monitoring cell division over a given time using label-free imaging.
  • Functional screening - In addition to monitoring growth, functional cell-based assays can be performed. This can include assays assessing differentiation potential, pluripotency, ability to form 3D organoids, and other desirable traits.
 

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