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RNAscope Technology

RNAscope^® is a novel multiplex nucleic acid in situ hybridization technology. ACD's unique patented probe design amplifies target-specific signals but not background noise, delivering clear and actionable results.

Although in situ RNA detection techniques (ISH and FISH) have been around for years, they are largely ineffective. They lack robustness and sensitivity to reliably detect the expression of most human genes. Microarray and PCR are gold standard molecular methods for disease profiling, but clinically relevant information regarding cellular and tissue context, as well as spatial variation of the expression patterns, is lost in the process.

Inspired to solve these challenges, ACD scientists revolutionized the RNA in situ hybridization method and in 2011 introduced RNAscope® ISH for detection of target RNA within intact cells. The assay represents a major advance in RNA ISH approaches, with its proprietary probe design that simultaneously amplify target-specific signals and suppress background noise from non-specific hybridization. Known for its sensitivity and specificity,  RNAscope® ISH is now a proven technology that has been featured in over 850 publications across a multitude of research areas. ACD offers both comprehensive Pharma Assay Services and Products for the assay to be conducted in research labs: kits, accessories and catalog probes for over 15,000 targets in over 140 species.